Preparation of 2-(3-aminopropyl)-cycloalkylamines

US5239120A · kind A · utility

Assignee

• BASF SE

Inventors

• Franz Merger · Bischofswerda, DE
• Claus-Ulrich Priester · Ludwigshafen, DE
• Gerhard Koppenhoefer · Ludwigshafen, DE
• Wolfgang Harder · Weinheim, DE
• Tom Witzel · Ludwigshafen, DE
• Helmut Lermer · Ludwigshafen, DE
• Ulrich Koehler · Heidelberg, DE

Key dates

• Filing date: Mar 27, 1991
• Grant date: Aug 24, 1993
• Expiry date: Mar 27, 2011

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2601/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A process for the preparation of a 2-(3-aminopropyl)-cycloalkylamine of the general formula I ##STR1## in which the subscript n is an integer from 1 to 4, from a 2-(2-cyanoethyl)-cycloalkanone of the general formula II ##STR2## in which the subscript n has the meaning stated, wherein the following stages are carried out in discrete reaction chambers: PA0 a) the 2-(2-cyanoethyl)-cycloalkanone of formula II is reacted in a first reaction chamber with excess ammonia over an acidic heterogeneous catalyst at a temperature from 20.degree. to 150.degree. C. and a pressure of from 15 to 500 bar, and PA0 b) in a second reaction chamber, the reaction product from stage a) is hydrogenated at a temperature of from 60.degree. to 150.degree. C. and a pressure of from 50 to 300 bar in the presence of excess ammonia over a catalyst containing cobalt, nickel, ruthenium, and/or some other noble metal, which catalyst optionally contains a basic component or is supported on neutral or basic supporting material.