Vaccine, antibodies & antibody-containing compositions for inhibiting human dental caries induced by streptococcus mutans
US5240704A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jun 22, 1992 |
| Grant date | Aug 31, 1993 |
| Priority date | — |
| Expiry date | Jun 22, 2012 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
PLS antigens I and II are derived from the pili-like structures on the cell wall of Human type Streptococcus mutans of the serotypes c, e, f and g and the serotype d, respectively and capable of specifically inhibiting the adherence (infection) of the corresponding strains to the teeth of humans. These antigens are a kind of glycoprotein comprising protein (about 15-25%) and carbohydrates (about 75-85%) and have a molecular weight of about 60,000-90,000. It is possible to isolate these antigen by extracting the intact cells in a hypertonic buffer solution at a pH of 6-8 and at a temperature below the denaturing point of the antigenic protein and fractionating the resultant antigen from the extract thereby obtained. A non-cariogenic vaccine comprises as antigen PLS antigens I and/or II. Non-cariogenic antibodies may be obtained by immunizing a mammal with PLS antigens I and/or II to produce the corresponding antibodies in the body of the mammal and recovering the resultant antibodies from the mammal. Non-cariogenic compositions comprises an effective amount of antibodies to PLS antigens I and/or II in association with a pharmaceutical carrier or excipient which may preferably suitab…
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