Antihypertensive compounds produced by fermentation
US5240910A · kind A · utility
31Cited by
3References
2Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Apr 17, 1992 |
| Grant date | Aug 31, 1993 |
| Priority date | — |
| Expiry date | Apr 17, 2012 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Novel cyclic depsipeptides derived from a culture of Microbispora are antagonists of the receptor for endothelin, a potent vasoconstrictor, and are thus useful in treating cardiovascular disorders. Endothelin has other physiological effects, and the endothelin receptor antagonists of the present invention thus also have other therapeutic uses. The compounds are cyclical depsipeptides of N-(pyrrol-2-carboxy) - L-phe, D-allo-Thr, D-Phe, D-Ala, D- or L-dihydroxyphenyl-Gly, and D-dihydroxyphenyl-Gly.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.