Method and compositions for inhibiting tumor cell metabolism
US5240914A · kind A · utility
9Cited by
13References
18Claims
0Family size
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Key dates
| Filing date | Dec 22, 1992 |
| Grant date | Aug 31, 1993 |
| Priority date | — |
| Expiry date | Dec 22, 2012 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K47/54
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The metabolism of tumor cells which have .beta.-glucuronidase activity is inhibited by administering to a patient a conjugate of glucuronic acid and a thiocarbamate compound of the formula: ##STR1## wherein R.sup.1 and R.sup.2 are selected from the group consisting of C.sub.1 -C.sub.6 alkyl and C.sub.1 -C.sub.6 cycloaliphatic, and M is selected from the group consisting of hydrogen, an electropositive, ionically bonded metal, and the radical ##STR2## and R.sup.3 and R.sup.4 are selected from the group consisting of C.sub.1 -C.sub.6 alkyl and C.sub.1 -C.sub.6 cycloaliphatic groups.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.