Oxysalicylamido derivatives

US5240957A · kind A · utility

Assignee

• Astra Lakemedel Aktiebolag · SE

Inventors

• Karl S. Bengtsson · Haditha, IQ
• Thomas Hogberg · Gately Drive, SE
• Lars George Johansson · Hagfors, SE
• Tomas DePaulis · Åkersberga, SE
• Hans Eric Peter Strom · Trosa, SE
• Marianne E. Widman · Täby, SE
• Sven O. gren · Gately Drive, SE

Key dates

• Filing date: Oct 29, 1990
• Grant date: Aug 31, 1993
• Expiry date: Oct 29, 2010

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C65/21
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Novel therapeutically active compounds of the formula ##STR1## wherein Z.sup.i, being Z.sup.1, Z.sup.2 or Z.sup.3, is the same or different and selected among OH, OR.sup.1, NH.sub.2, NR.sub.2.sup.4, NHR.sup.4, SH, SR.sup.4 and OR.sup.4 wherein R.sup.1 is a formyl group, an acyl group, an alkoxycarbonyl group or a mono- or dialkylcarbamoyl group and R.sup.4 is a lower alkyl group, PA0 R.sup.2 is a hydrogen, a halogen, a lower alkyl or a lower trifluoroalkyl group, PA0 R.sup.3 is a hydrogen atom, a lower alkyl group, an alkenyl group, an alkynyl group or a phenyl group, which phenyl group could optionally be substituted by one or more of fluoro, chloro, bromo, trifluoromethyl, methyl, ethyl, methoxy or ethoxy in the ortho, meta or para positions, or optionally substituted by methylenedioxy, provided that at least one of Z.sup.1, Z.sup.2 and Z.sup.3 is a group OR.sup.4 and further provided that when Z.sup.2 is OH or NH.sub.2, Z.sup.1 is NR.sub.2.sup.4, NHR.sup.4, SH, SR.sup.4 or OR.sup.4 or a physiologically acceptable salt or optical isomer thereof, intermediates and methods for their preparation, pharmaceutical preparations containing the compounds and methods for their therapeutica…