Coupling agents and sterically hindered disulfide linked conjugates prepared therefrom
US5241078A · kind A · utility
30Cited by
7References
9Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Feb 14, 1992 |
| Grant date | Aug 31, 1993 |
| Priority date | — |
| Expiry date | Feb 14, 2012 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/532
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
This invention discloses heterobifunctional coupling agents for making a wide array of molecular conjugates. The agents contain a sterically hindered thiol, linked through a spacer arm to a second group reactive toward nucleophiles such as 1.degree. and 2.degree. amines or reactive thiols that are present on biological and organic materials. The coupling agents are useful for making conjugates containing a sterically hindered linkage.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.