Catheter device and method of use for intramural delivery of protein kinase C and tyrosine protein kinase inhibitors to prevent restenosis after balloon angioplasty
US5242397A · kind A · utility
98Cited by
10References
12Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jan 2, 1992 |
| Grant date | Sep 7, 1993 |
| Priority date | — |
| Expiry date | Jan 2, 2012 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61M2025/1086
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention discloses a method of treatment of an atherosclerotic blood vessel. Protein kinase C and tyrosine protein kinase inhibitors are delivered by means of a specialized catheter system to the deeper layers of the vessel wall with only minimal interruption of the vessel endothelium. This system will allow high local concentrations of otherwise toxic agents directly at the site of an atherosclerotic plaque to prevent and/or reduce the incidence of late restenosis attributed to cellular hyperplasia or rethrombosis.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.