Defensin peptide compositions and methods for their use

US5242902A · kind A · utility

Assignee

• The Regents of the University of California · US

Inventors

• Christopher Murphy · Madison, US
• Ted W. Reid · Lubbock, US
• Mark Mannis · Rancho Cordova, US
• Bradley A. Foster · Davis, US
• James S. Cullor · Woodland, US
• Michael E. Selsted · Los Angeles, US
• Robert I. Lehrer · Santa Monica, US
• Tomas Ganz · Los Angeles, US

Key dates

• Filing date: Sep 6, 1989
• Grant date: Sep 7, 1993
• Expiry date: Sep 6, 2009

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S930/19
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A method for treating cutaneous and corneal wounds as well as certain microbial-related diseases comprises topically applying a defensin peptide to the affected tissue. The compositions comprise a natural, synthetic, or analog defensin molecule having both a mitogenic activity capable of stimulating cell growth and an antimicrobial activity capable of inhibiting the growth of a wide variety of pathogens. In addition to therapeutic use, the defensins are useful as mitogens in cell and tissue culture media.