Piperazinylbenzodioxane derivatives

US5242925A · kind A · utility

Assignee

• Merck Patent GmbH · DE

Inventors

• Henning Boettcher · Darmstadt, DE
• Christoph Seyfried · Seeheim-Jugenheim, DE
• Hartmut Greiner · Darmstadt, DE
• Gerd Bartoszyk · Weiterstadt, DE

Key dates

• Filing date: Aug 24, 1992
• Grant date: Sep 7, 1993
• Expiry date: Aug 24, 2012

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D453/02
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Piperazinylbenzodioxane derivatives of formula I ##STR1## wherein B is an indol-3-yl or benzimidazol-1-yl radical which is unsubstituted or monosubstituted by CN, CO--R.sup.1, C.sub.n H.sub.2n --R.sup.1, Hal, OH, OA, O--C.sub.n H.sub.2n --CO--R.sup.1, or NHR.sup.2, and Q is C.sub.n H.sub.2n, or a physiologically acceptable salt thereof. The derivatives are active in the central nervous system, especially as serotonin agonists and antagonists.