Genetic detoxification of pertussis toxin
US5244657A · kind A · utility
16Cited by
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4Claims
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Key dates
| Filing date | Sep 28, 1990 |
| Grant date | Sep 14, 1993 |
| Priority date | — |
| Expiry date | Sep 28, 2010 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S424/832
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A new method is described for the preparation of a safe, immunogenic and efficacious vaccine for protection against the disease pertussis. In development of this vaccine, specific functional sites of pertussis toxin have been identified, and using this information, defined mutant holotoxins have been produced by site directed mutagenesis of the toxin gene. A number of these holotoxin analogs are detoxified, retain an immunodominant S1 epitope, are immunogenic and are protective in the standard pertussis vaccine potency test in mice.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.