Stable porfimer sodium compositions and methods for their manufacture
US5244914A · kind A · utility
4Cited by
4References
5Claims
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Key dates
| Filing date | Apr 27, 1992 |
| Grant date | Sep 14, 1993 |
| Priority date | — |
| Expiry date | Apr 27, 2012 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P35/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A storage stable porfimer sodium (polyhematoporphyrin ether/ester) composition useful in the photodynamic therapy of cancer and other conditions is provided. The composition is characterized in that the percentage of ester linked porphyrin oligomers is less than 10% of the composition. Improved processes for preparing such compositions are also provided wherein acetylated hematoporphyrin is treated with alkali for sufficient time and temperature to reduce the amount of porphyrin oligomers joined by ester linkages to less than 10% of the composition.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.