Amico acid derivatives cyclized at the C-terminal
US5244915A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jul 12, 1991 |
| Grant date | Sep 14, 1993 |
| Priority date | — |
| Expiry date | Jul 12, 2011 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D209/20
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Novel .alpha.-substituted Trp dipeptoid derivatives cyclized at the C-terminal useful as agents in the treatment of obesity, hypersecretion of gastric acid in the gut, gastrin-dependent tumors, or as antipsychotics are disclosed. Further, the compounds are antianxiety agents and antiulcer agents. They are agents useful for preventing the response to the withdrawal from chronic treatment with or use of nicotine, diazepam, alcohol, cocaine, caffeine, or opioids. The compounds of the invention are also useful in treating and/or preventing panic attacks. Also disclosed are pharmaceutical compositions and methods of treatment using the compounds as well as processes for preparing them and novel intermediates useful in their preparation. An additional feature of the invention is the use of the compounds in diagnostic compositions.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.