Exonuclease resistant terminally substituted oligonucleotides
US5245022A · kind A · utility
245Cited by
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26Claims
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Assignee
Inventors
Key dates
| Filing date | Aug 3, 1990 |
| Grant date | Sep 14, 1993 |
| Priority date | — |
| Expiry date | Aug 3, 2010 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H21/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Compounds, compositions and methods for inhibiting gene expression are disclosed. The compounds comprise oligonucleotide sequences of from about 9 to about 200 bases having a diol at either or both termini. Preferred diols are polyalkyleneglycols, preferably polyethyleneglycols. Pharmaceutical compositions comprising the compounds and a physiologically acceptable carrier and methods of inhibiting gene expression in mammals comprising administering such compounds are also provided. Methods for inhibiting nuclease cleavage of compounds are also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.