Substituted pyridinylamino-1,2-benzisothiazoles and their use for treating depression
US5246947A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Aug 7, 1992 |
| Grant date | Sep 21, 1993 |
| Priority date | — |
| Expiry date | Aug 7, 2012 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D417/12
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
This invention relates to substituted pyridinylamino-1H-indoles, 1H-indazoles, 2H-indazoles, benzo[b]thiophenes and 1,2-benzisothiazoles of the formula ##STR1## wherein Q is S, N or NR.sub.2 ; PA1 Y is CH, N or NR.sub.2 ; PA1 R.sub.1 is hydrogen, loweralkyl, loweralkynyl, loweralkenyl, arylloweralkyl, loweralkoxycarbonylaminoloweralkylcarbonyl, arylloweralkoxycarbonylaminoloweralkylcarbonyl, aminoloweralkylcarbonyl, loweralkoxycarbonyl or acyl; PA1 R.sub.2 is hydrogen or loweralkyl; PA1 R.sub.3 is hydrogen or loweralkyl; PA1 X is hydrogen, loweralkyl, halogen; and PA1 n is 0 or 1; or a pharmaceutically acceptable acid addition salt thereof. The compounds of this invention are useful in the treatment of memory dysfunctions characterized by a cholinergic deficit such as the type associated with Alzheimer's disease and other memory disorders. Compounds of this invention also have utility as modulators of neurotransmitter function such as noradrenergic and serotonergic and as such are useful for treatment of depression and personality disorders such as obsessive compulsive disorders. Additionally, compounds of this invention are useful as topical antiinflammatory agents for the treatme…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.