Surface modified liposomes
US5248590A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jul 22, 1991 |
| Grant date | Sep 28, 1993 |
| Priority date | — |
| Expiry date | Jul 22, 2011 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S436/829
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A liposome reagent encapsulating a molecule to be targeted to a body site or used as an assay reporter has a ligand and a sulfonate-containing group on the liposome surface. Preferred ligands are antibodies or antibody fragments and preferred encapsulants are enzymes or dyes. In the most preferred reagents, the antibody and sulfonate-containing group are covalently bonded to the liposome surface through a connecting group which includes a succinimidyl group resulting from addition of the ligand or sulfonate-containing group to a maleimidyl group. The invention includes a kit of materials for performing an assay using the reagent of the invention as the tracer.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.