Process and reagent for the determination of the luteinizing hormone and monoclonal antibodies suitable thereof

US5248593A · kind A · utility

Assignee

• Boehringer Mannheim GmbH · DE

Inventors

• Christa Hubner-Parajsz · Tutzing, DE
• Hartmut Schetters · Neufahrn, DE
• Helmut Lenz · Tutzing, DE
• Klaus Erler · Pöcking, DE

Key dates

• Filing date: Jun 29, 1992
• Grant date: Sep 28, 1993
• Expiry date: Jun 29, 2012

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K16/26
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The present invention provides an immunological process for the determination of the luteinizing hormone (LH), wherein at least one monoclonal antibody is used which is directed against LH and cross-reacts with other glycoprotein hormones to an extent of less than 3%. The present invention also provides a reagent for the determination of the luteinizing hormone, wherein it contains at least one monoclonal antibody which is directed against LH and cross-reacts with other glycoprotein hormones to an extent of less than 3%. Furthermore, the present invention provides a monoclonal antibody against the luteinizing hormone and a process and a hybridoma cell line for producing it.