Patent · US Expired

Method of detecting proteolytically modified antithrombin

US5248596A · kind A · utility

3Cited by

4References

2Claims

0Family size

Assignee

Miles Inc. · US

Inventors

Pamela C. Esmon · Richmond, US
Emma Yee · Albany, US
Robert Jordan · Walnut Creek, US
Richard M. Nelson · Lafayette, US

Key dates

Filing date	Mar 2, 1992
Grant date	Sep 28, 1993
Priority date	—
Expiry date	Mar 2, 2012

Classification

Technology area (CPC Y)Emerging Cross-Sectional Technologies
CPC primaryY10S435/967
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

Indirect method of detecting elastase-modified or cleaved, antithrombin (ATx) in the presence of intact antithrombin (AT-III). The inventive method includes a modified ELISA using a detergent to alter the intact AT-III. Cleaved AT-III is generated in human plasma, then an ELISA is performed in the presence of a detergent.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.