Superoxide dismutase

US5248603A · kind A · utility

Assignee

• Symbicom Aktiebolag · SE

Inventors

• Stefan Marklund · Uppsala, SE
• Thomas Edlund · Umeå, SE

Key dates

• Filing date: Jun 12, 1992
• Grant date: Sep 28, 1993
• Expiry date: Jun 12, 2012

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N9/0089
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A superoxide dismutase originally found in extracellular body fluids and therefore termed extracellular superoxide dismutase (EC-SOD) is prepared by growing a cell line, preferably of mammalian origin, producing EC-SOD and recovering the EC-SOD secreted from the cells or by inserting a DNA sequence encoding EC-SOD into a suitable vector, introducing the recombinant vector into a host cell, growing the cell and recovering the EC-SOD produced. EC-SOD may be used for the prophylaxis or treatment of diseases or disorders associated with the presence or formation of superoxide radicals.