Process for preparing no-carrier-added radiohalogenated vinyl nucleosides
US5248771A · kind A · utility
6Cited by
2References
15Claims
0Family size
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Inventor
Key dates
| Filing date | Jun 26, 1991 |
| Grant date | Sep 28, 1993 |
| Priority date | — |
| Expiry date | Jun 26, 2011 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S436/804
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Reacting [.sup.* X]X- with YVaraU in the presence of a cuprous ion catalyst under anaerobic and reducing conditions produces [.sup.* X]XVaraU, where .sup.* X is a radioactive halogen, Y is a second halogen, X and Y are different halogens, and XVaraU is 1-(.beta.-D-arabinofuranosyl)-5(E)-(2-halogenovinyl) uracil, the halogen of which is X. The reaction produces an effective administrable form of [.sup.* X]XVaraU for use in diagnosis and treatment of herpes virus infections.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.