Method of preparation of 8-hydroxyoctanoic acid

US5248798A · kind A · utility

Assignee

• Natterman, A. & Cie. GmbH · DE

Inventors

• Bernd-Rainer Gunther · Garching bei München, DE
• Rainer Losch · Bonn, DE
• Hans-Heiner Lautenschlager · Pulheim, DE
• Klaus Steiner · Pulheim, DE

Key dates

• Filing date: Jul 22, 1991
• Grant date: Sep 28, 1993
• Expiry date: Jul 22, 2011

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C51/38
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention refers to a novel method for the preparation of 8-hydroxyoctanoic acid by reaction of 6-chlorohexanol with a dialkyl malonate ester, thermal decarboxylation of the malonic acid derivative and isolation of the 8-hydroxyoctanoic acid as the free acid or as an alkali metal salt.