Improved perfusion medium for transplantation of organs
US5250294A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Nov 17, 1992 |
| Grant date | Oct 5, 1993 |
| Priority date | — |
| Expiry date | Nov 17, 2012 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/49
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
In accordance with the present invention, a composition and method is provided for perfusion of organs. The present invention includes perfusion of organs in situ and before transplantation. The method comprises perfusing an organ with a perfusion medium containing an effective amount of a surface active copolymer. The surface active copolymer can be an ethylene oxide-propylene oxide condensation product with the following general formula: EQU HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O).sub.b H wherein a is an integer such that the hydrophobe represented by (C.sub.3 H.sub.6 O) has a molecular weight of approximately 950 to 4000, preferably approximately 1200 to 3500, and b is an integer such that the hydrophile portion represented by (C.sub.2 H.sub.4 O) constitutes approximately 50% to 90% by weight of the compound.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.