Bile acid derivatives, process for their preparation and use of these compounds as pharmaceuticals

US5250524A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Werner Kramer · Schwandorf, DE
• Gunther Wess · Niederrodenbach, DE
• Stefan Mullner · Langenfeld, DE
• Horst Neubauer · Königstein, DE

Key dates

• Filing date: Dec 4, 1991
• Grant date: Oct 5, 1993
• Expiry date: Dec 4, 2011

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07J41/0094
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention relates to bile acid derivatives of the formula I EQU G1--X--G2 (I) in which PA1 G1 and G2 are bile acid radicals or modified bile acid radicals in the form of the free acids, the esters or amides, the salt forms and also the forms derivatized on the alcohol groups and PA1 X is a bridge group or a single covalent bond, it being possible for G1 and G2 to be optionally bonded via X. The compounds according to the invention have a high affinity for the specific bile acid transport system of the small intestine and inhibit bile acid absorption in a concentration-dependent and competitive manner.