Substituted 9-(1 or 3-monoacyloxy or 1,3-diacyloxy-2-propoxymethyl) purines as antiviral agent

US5250535A · kind A · utility

Assignee

• Syntex LLC · PA

Inventors

• Julien P. H. Verheyden · Los Altos, US
• John C. Martin · Los Alamos, US

Key dates

• Filing date: Dec 22, 1982
• Grant date: Oct 5, 1993
• Expiry date: Dec 22, 2002

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C43/1786
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds useful as antiviral agents are defined by the following formula: ##STR1## and the pharmaceutically acceptable acid addition salts thereof wherein R.sup.1 is hydrogen or --C(O)R.sup.7 wherein R.sup.7 is hydrogen, alkyl of one to nineteen carbon atoms, hydroxyalkyl of one to eight carbon atoms, alkoxyalkyl of two to nine carbon atoms, alkenyl of two to nineteen carbon atoms, phenyl, 1-adamantyl or 2-carboxyethyl and the pharmaceutically acceptable alkali metal salts thereof; PA1 R.sup.2 is --C(O)R.sup.7 wherein R.sup.7 is as defined above; PA1 R.sup.3 is hydrogen, halo, thio, lower alkylthio of one to six carbon atoms, azido, NR.sup.9 R.sup.10 wherein R.sup.9 and R.sup.10 are independently hydrogen or lower alkyl of one to six carbon atoms or --NHC(O)R.sup.8 wherein R.sup.8 is hydrogen, alkyl of one to nineteen carbon atoms or 1-adamantyl; and PA1 (a) R.sup.6 is hydrogen, halo, lower alkoxy of one to six carbon atoms, azido, thio, lower alkylthio of one to six carbon atoms, --NR.sup.9 R.sup.10 wherein R.sup.9 and R.sup.10 are as defined above or --NHC(O)R.sup.8 wherein R.sup.8 is as defined above and R.sup.4 together with R.sup.5 is a bond; or PA1 (b) R.sup.5 together with …