Benzopyran derivatives
US5250547A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Aug 29, 1991 |
| Grant date | Oct 5, 1993 |
| Priority date | — |
| Expiry date | Aug 29, 2011 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P15/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Compounds of the Formula: ##STR1## wherein: R.sup.1 and R.sup.2 are independently hydrogen or lower alkyl, or when taken together with the carbon to which they are attached are cycloalkyl of 3 to 8 carbon atoms; PA1 R.sup.3 is fluoro lower alkyl; cyano; or nitro; PA1 R.sup.4 is ##STR2## R.sup.5 and R.sup.6 are independently hydrogen or lower alkyl; and R.sup.7 is --NR.sup.8 R.sup.9 ; wherein: PA2 R.sup.8 is hydrogen; lower alkyl; lower alkoxy; hydroxy; or hydroxy lower alkyl; and PA2 R.sup.9 is hydrogen; lower alkyl; hydroxy lower alkyl; --SO.sub.2 R.sup.10 ; --CO.sub.2 R.sup.10 ; --C(O)NR.sup.11 R.sup.12 ; --C(S)NR.sup.11 R.sup.12 ; or --C(O)R.sup.12 ; PA2 wherein PA3 R.sup.10 is lower alkyl; PA3 R.sup.11 is hydrogen or lower alkyl; and PA3 R.sup.12 is hydrogen, lower alkyl, or fluoro lower alkyl; with the proviso that R.sup.8 and R.sup.9 cannot both be hydrogen; and the pharmaceutically acceptable salts thereof. The compounds and salts exhibit useful pharmacological properties, including potassium channel activating properties and 5-lipoxygenase inhibiting properties, and in particular are useful as smooth muscle relaxants and bronchodilators.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.