2-oxo-5-mercaptomethylimidazolidine-4-ols

US5250699A · kind A · utility

Assignee

• Merck Patent GmbH · DE

Inventors

• Michael Casutt · Pfungstadt, DE
• Eike Poetsch · Mühltal, DE
• Willem N. Speckamp · Heiloo, NL

Key dates

• Filing date: Apr 10, 1991
• Grant date: Oct 5, 1993
• Expiry date: Apr 10, 2011

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02P20/55
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention relates to a process for the preparation of D-(+)-biotin, from a cysteine hydantoin of the formula I ##STR1## in which R.sup.1 is H, or a group R.sup.3 R.sup.4 CH-- or SiR.sup.5 R.sup.6 R.sup.7, in which PA1 R.sup.3 and R.sup.4 in each case independently of one another are H, unsubstituted or substituted alkyl, cycloalkyl, aryl, aralkyl or heteroaryl or, taken together, are unsubstituted or substituted alkylene or heteroalkylene, PA1 R.sup.5, R.sup.6 and R.sup.7 in each case independently of one another are unsubstituted or substituted alkyl, cycloalkyl, aryl, aralkyl or heteroaryl, PA0 R.sup.2 is H or a protective group suitable for a nitrogen atom and PA0 X is O, S or N--R.sup.8, in which PA1 R.sup.8 is an alkyl, cycloalkyl, aryl or alkoxycarbonyl group or a dialkylamino group and to intermediates which are passed through in this process.