Optically active cyclic amine and the process of optical resolution therefor
US5250705A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Oct 1, 1992 |
| Grant date | Oct 5, 1993 |
| Priority date | — |
| Expiry date | Oct 1, 2012 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention relates to process for the isolation of (-)-(S)-3-methylamino-4-methylenepyrrolidine derivatives of the formula: ##STR1## wherein R is hydrogen or amino-protecting group, from the racemic mixture of them comprising the salt formation of the racemate with L-(+)-tartaric acid in a molar ratio of 2:1 and subsequent treatment with a base, and optionally followed by deprotection of the amino-protecting group. By this process, complicated procedure in resolutional crystallization is not necessary and (-)-(S)-3-methylamino-4-methylenepyrrolidine derivatives can be obtained as optically pure form in above 90% yield quantitatively by single procedure.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.