Tablets and granulates containing mesna as active substance

US5252341A · kind A · utility

Assignee

• Degussa AG · DE

Inventors

• Dieter Sauerbier · Altentreptow, DE
• Jurgen Engel · Alzenau, DE
• Eckhard Milsmann · Bielefeld, DE

Key dates

• Filing date: Aug 17, 1992
• Grant date: Oct 12, 1993
• Expiry date: Aug 17, 2012

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K31/185
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A granulate containing mesna is made by granulating mesna in the presence of an alcohol, acetone or a mixture of one of these with water. The granulate may be converted to tablets, along with other agents. The tablets contain PA0 0.01-1 parts by weight of a binding agent PA0 0.03-0.4 parts by weight of a disintegrant PA0 0.01-0.2 parts by weight of a lubricant and PA0 0.1-1 parts by weight of a filling agent as well as, in the case of an effervescent tablet, an additional 0.05-30 parts by weight of a conventional physiologically acceptable effervescent mixture.