Mutant of bacterium Clostridium histolyticum, a process for the obtaining thereof, and its use in the production of clostripain-free collagenase
US5252481A · kind A · utility
15Cited by
4References
7Claims
0Family size
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Key dates
| Filing date | Jul 23, 1991 |
| Grant date | Oct 12, 1993 |
| Priority date | — |
| Expiry date | Jul 23, 2011 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S435/842
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A mutant of bacterium Clostridium histolyticum, designated Clostridum histolyticum K26 clo 88 of the following characteristics: the lack of a motility system which is a fundamental characteristic of the parenteral strain; and, the inability to biosynthesize the accompanying enzyme clostripain. A process of obtaining the above mutant and its use in a process for the production of clostripain-free collagenase are also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.