Patent · US Expired

Acetohydroxamic compound and complexes pharmaceutical compositions containing them and processes of preparation and use

US5252562A · kind A · utility

0Cited by

5References

13Claims

0Family size

Assignee

Gruenenthal GmbH · DE

Inventors

Ulrich Seipp · Aachen, DE
Werner Englberger · Stolberg, DE
Michael Haurand · Aachen, DE
Johannes Schneider · Stolberg, DE

Key dates

Filing date	Jul 10, 1992
Grant date	Oct 12, 1993
Priority date	—
Expiry date	Jul 10, 2012

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D333/20
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

An acetohydroxamic acid compound of formula I ##STR1## as such or in form of a complex with .beta.-cyclodextrin or hydroxypropyl-.beta.-cyclodextrin specifically inhibits 5-lipoxygenase and is useful in pharmaceutical compositions for prophylaxis and treatment of diseases due to the action of leucotrienes. The acetohydroxamic acid compound may be prepared by reacting 3-thiophenecarboxaldehyde with hydroxylamine or a salt thereof to form the corresponding oxime, reducing the oxime with a boron-containing reducing agent to form N-(thien-3-yl)methyl-hydroxylamine, and introducing an acetyl group.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.