Pyridopyrimidine derivatives, pharmaceutical compositions containing them and process for preparing same
US5252572A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jun 23, 1992 |
| Grant date | Oct 12, 1993 |
| Priority date | — |
| Expiry date | Jun 23, 2012 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D471/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention relates to novel 4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxamide derivatives of the general formula (I) and the acid addition salts thereof, pharmaceutical compositions containing them and a process for their preparation. In the general formula (I) ##STR1## R stands for a C.sub.1-12 alkyl group optionally substituted by a C.sub.1-4 alkoxycarbonyl group; a C.sub.3-9 cycloalkyl, adamantyl or optionally substituted phenyl group; PA0 R.sup.1 means hydrogen or a C.sub.1-4 alkyl group; or PA0 R and R.sup.1 together form a --(CH.sub.2).sub.n -- chain, wherein n is 4, 5 or 6; PA0 R.sup.2 stands for hydrogen, a C.sub.1-4 alkyl group or halogen; PA0 R.sup.3 represents hydrogen or a C.sub.1-4 alkyl group; and PA0 m is 0 or 1. The compounds of the general formula (I) possess a gastroprotective effect and are useful for the prevention and therapy of ulcers of the stomach and the small intestine.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.