Preparation process for a protein containing at least one intramolecular disulphide bridge by oxidation, at a pH of less than 5.0 of corresponding reduced recombinant protein
US5252708A · kind A · utility
8Cited by
6References
11Claims
0Family size
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Key dates
| Filing date | May 6, 1992 |
| Grant date | Oct 12, 1993 |
| Priority date | — |
| Expiry date | May 6, 2012 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K14/55
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Preparation process for a protein comprising at least one intramolecular disulphide bridge, and optionally one or more additional cysteines, comprising the oxidation of the corresponding reduced recombinant protein using an oxidizing agent and characterized in that an aqueous solution of the reduced protein is reacted at a pH of less than 5.0.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.