D-heteroaryl, O-alkylheteroaryl, O-alkenylheteroaryl and O-alkynylheteroarylmacrolides having immunosuppressive activity
US5252732A · kind A · utility
28Cited by
4References
17Claims
0Family size
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Key dates
| Filing date | Aug 5, 1992 |
| Grant date | Oct 12, 1993 |
| Priority date | — |
| Expiry date | Aug 5, 2012 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P37/06
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
O-Heteroaryl, O-alkylheteroaryl, O-alkenylheteroaryl and O-alkynylheteroarylmacrolides of the general structural Formula I: ##STR1## have been prepared from suitable precursors by alkylation and/or arylation at C-3" and/or C-4" of the cyclohexyl ring. These macrolide immunosuppressants are useful in a mammalian host for the treatment of autoimmune diseases, infectious diseases, the prevention of rejection of foreign organ transplants and/or related afflictions, diseases and illnesses.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.