Substituted 1,3-diazines as leukocyte elastase inhibitors
US5254558A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Aug 14, 1992 |
| Grant date | Oct 19, 1993 |
| Priority date | — |
| Expiry date | Aug 14, 2012 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to certain novel substituted heterocycles which are 1-pyrimidinylacetamide compounds of formula I, set out herein, which are inhibitors of human leukocyte elastase (HLE), also known as human neutrophil elastase (HNE), making them useful whenever such inhibition is desired, such as for research tools in pharmacological, diagnostic and related studies and in the treatment of diseases in mammals in which HLE is implicated. The invention also includes intermediates useful in the synthesis of these substituted heterocycles, processes for preparing the substituted heterocycles, pharmaceutical compositions containing such substituted heterocycles and methods for their use.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.