Substituted isoquinoline compounds, pharmaceutical composition and method of use in treating pain in mammals

US5254564A · kind A · utility

Assignee

• Lo Zambeletti S.p.A. · IT

Inventors

• Vittorio Vecchietti · Baranzate, IT
• Giuseppe Giardina · Milano, IT
• Roberto Colle · Milano, IT

Key dates

• Filing date: Jul 16, 1990
• Grant date: Oct 19, 1993
• Expiry date: Jul 16, 2010

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D221/16
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A compound, or a solvate or salt thereof, of formula (I): ##STR1## in which: RCO is an acyl group in which the group R contains a substituted or unsubstituted carbocyclic aromatic or heterocyclic aromatic ring and R.sub.1 and R.sub.2 are independently hydrogen, C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.3-6 cycloalkyl or C.sub.4-12 cycloalkylalkyl groups or together form a C.sub.2-8 branched or linear polymethylene or C.sub.2-6 alkenylene group optionally substituted with a hetero-atom; PA1 R.sub.3 is hydrogen, C.sub.1-6 alkyl, preferably methyl or ethyl, .sup.4 or phenyl, or R.sub.3 together with R.sub.1 forms a --(CH.sub.2).sub.3 -- or --(CH.sub.2).sub.4 --, group; PA1 R.sub.4 and R.sub.5 are identical and are hydrogen or C.sub.1-6 alkyl, or together form a C.sub.2-5 linear polymethylene group; R.sub.6 and R.sub.7 are identical and are hydrogen or C.sub.1-6 alkyl, or together form a C.sub.2-5 linear polymethylene group; PA1 or R.sub.5 and R.sub.6 are together --CH.sub.2 -- when each of R.sub.4 and R.sub.7 is hydrogen or C.sub.1-6 alkyl; PA1 with the proviso that R.sub.4, R.sub.5, R.sub.6 and R.sub.7 are not simultaneously hydrogen; PA1 R.sub.8 and R.sub.9, which may be the same or…