Cyclic renin inhibitors containing 3(S)-amino-4-cyclohexyl-2(R)-hydroxy-butanoic acid or 4-cyclo-hexyl-(2R, 3S)-dihydroxybutanoic acid or related analogs
US5254682A · kind A · utility
9Cited by
6References
15Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jun 11, 1991 |
| Grant date | Oct 19, 1993 |
| Priority date | — |
| Expiry date | Jun 11, 2011 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Compounds of the formula: ##STR1## are disclosed. These compounds inhibit the angiotensinogen-cleaving action of the natural proteolytic enzyme, renin, and are useful in treating, preventing or managing renin-associated hypertension, hyperaldosteronism, congestive heart failure, and glaucoma.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.