2,6-dialkyl-4-(benzothiazol- or benzoxazol-7-yl)-1,4-dihydropyridines

US5254692A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Siegfried Goldmann · Wuppertal, DE
• Horst Boshagen · Haan, DE
• Jurgen Stoltefuss · Haan, DE
• Alexander Straub · Wuppertal, DE
• Rainer Gross · Wuppertal, DE
• Joachim Hutter · Leverkusen, DE
• Siegbert Hebisch · Wuppertal, DE
• Martin Bechem · Wuppertal, DE

Key dates

• Filing date: Oct 15, 1992
• Grant date: Oct 19, 1993
• Expiry date: Oct 15, 2012

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D491/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

2,6-dialkyl-4-(benzothiazol- or benzoxazol-7-yl)-1,4-dihydropyridines which exhibit positive inotropic action with largely neutral vascular behavior, of the formula ##STR1## in which R.sup.1 and R.sup.5 are identical or different and represent straight-chain or branched alkyl having up to 8 carbon atoms, PA0 R.sup.2 represents nitro or cyano, or PA0 R.sup.1 and R.sup.2 together form a lactone ring of the formula ##STR2## R.sup.3 represents a radical of the formula ##STR3## and R.sup.4 represents hydrogen, or PA0 and physiologically acceptable salts thereof.