Substituted 3,4-dihydronaphthalenes, pharmaceutical compositions containing them, and preparation processes

US5254731A · kind A · utility

Assignee

• Gruenenthal GmbH · DE

Inventors

• Oswald Zimmer · Würselen, DE
• Werner Vollenberg · Stolberg, DE
• Johannes Schneider · Stolberg, DE

Key dates

• Filing date: Jul 10, 1992
• Grant date: Oct 19, 1993
• Expiry date: Jul 10, 2012

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2602/28
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Substituted 3,4-dihydronaphthalenes of the formula I ##STR1## wherein R.sup.1 is a methyl or an amino group, R.sup.2 represents a hydrogen atom or a methyl group, and R.sup.3 is a linear or branched chain alkyl residue having 1 to 4 carbon atoms, an allyl or a crotyl group or a cyclopentyl group are disclosed which specifically inhibit 5-lipoxygenase and are useful in pharmaceutical compositions for prophylaxis and treatment of disorders attributable to the action of leucotrienes. The dihydronaphthalenes may be prepared by reacting a compound of formula II ##STR2## with hydroxylamine or a salt thereof to form the corresponding oxime, reducing the oxime to a hydroxylamine of formula III ##STR3## and introducing a --CO--R.sup.1 group.