Selective inhibition of gene expression by photoactivatable oligonucleotides
US5256648A · kind A · utility
11Cited by
1References
40Claims
0Family size
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Key dates
| Filing date | Sep 21, 1989 |
| Grant date | Oct 26, 1993 |
| Priority date | — |
| Expiry date | Sep 21, 2009 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2310/3521
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method of inhibiting the function of targeted DNA in a viable cell comprising administering to a viable cell containing targeted DNA a therapeutically effective amount of a photoactivatable composition comprising the UVA irradiation product of a compound that has two photoactivatable functional groups, and an oligonucleotide of DNA whose sequence of bases (a) contains at least one TA or AT sequence and (b) is substantially complementary to a segment of cellular DNA of the targeted DNA in the cell, and irradiating the cell with UVA light.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.