Aminopyrimidine derivatives as antiviral agents for respiratory syncytial virus

US5256668A · kind A · utility

Assignee

• Amerimas Home Products, Inc. · US

Inventors

• Kuo-Hom L. Hsu · Fort Washington, US
• Daniel M. Teller · Columbus, US
• Alan R. Davis · Plainwell, US
• Michael D. Lubeck · Glenmoore, US
• Jehan F. Bagli · Princeton, US

Key dates

• Filing date: Mar 17, 1993
• Grant date: Oct 26, 1993
• Expiry date: Mar 17, 2013

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K31/505
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Antiviral activity against respiratory syncytial virus has been found in some substituted 6-aminopyrimidines having the formula: ##STR1## wherein R.sup.1 is lower alkyl, preferably methyl or t-butyl, R.sup.2 is halogen or cyano, and R.sup.3 is C.sub.1 -C.sub.6 alkyl or --(CH.sub.2).sub.n R.sup.4 where n is 1 or 2 and R.sup.4 is phenyl, phenyl substituted by lower alkoxy, lower alkyleneoxy, bromo, or 3,4-methylenedioxy; 3 or 4-pyridinyl, pyridinyl substituted by cyano or bromo, thienyl, or di-(C.sub.1 -C.sub.6 alkyl)amino.