3,5-di-tertiary-butyl-4-hydroxyphenyl-1,3,4-thiadiazoles, and oxadiazoles and 3,5-di-tertiary-butyl-4-hydroxy-phenyl-1,2,4-thiadazoles, oxadiazoles and triazoles as antiinflammatory agents

US5256680A · kind A · utility

Assignee

• WARNER-LAMBERT COMPANY LLC · US

Inventors

• David T. Connor · Ann Arbor, US
• Daniel L. Flynn · Lawrence, US
• Catherine R. Kostlan · Saline, US
• Michael D. Mullican · Needham, US
• Gary P. Shrum · Ann Arbor, US
• Paul C. Unangst · Ann Arbor, US
• Michael William Wilson · Foster City, US

Key dates

• Filing date: Jun 29, 1992
• Grant date: Oct 26, 1993
• Expiry date: Jun 29, 2012

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D285/135
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention is novel compounds which are 3,5-di-tertiary-butyl-4-hydroxyphenyl substituted 1,2,4- and 1,3,4-thiadazoles and oxadiazoles, and 1,2,4-triazoles, and pharmaceutically acceptable additions and base salts thereof, pharmaceutical compositions and methods of use therefor. The invention compounds are now found to have activity as inhibitors of 5-lipoxygenase and/or cyclooxygenase providing treatment of conditions advantageously affected by such inhibition including inflammation, arthritis, pain, fever, and the like.