Oxidation resistant thrombomodulin analogs
US5256770A · kind A · utility
30Cited by
1References
3Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Apr 9, 1990 |
| Grant date | Oct 26, 1993 |
| Priority date | — |
| Expiry date | Apr 9, 2010 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Novel soluble oxidation resistant thrombomodulin analogs are produced for various therapeutic and other uses, such as in thrombotic and vascular disease therapies. These analogs exhibit the characteristic therapeutic properties of native thrombomodulin, yet they are soluble and are not inactivated after they have been exposed to oxidants. Some of the analogs disclosed are multifunctional fusion proteins having both antithrombotic activity and some additional bioactivity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.