Highly active, rapidly absorbable formulations of glibenclamide, processes for the production thereof and their use

US5258185A · kind A · utility

Inventors

• Kurt Bauer
• Manfred Keller · Munich, DE

Key dates

• Filing date: Aug 19, 1991
• Grant date: Nov 2, 1993
• Expiry date: Aug 19, 2011

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K9/146
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention relates to highly active and solid pharmaceutical preparations rapidly releasing the active substance for the treatment of diabetes, particularly: 1. liquid formulations of glibenclamide consisting of 1 part of glibenclamide and 4 to 1500 parts of liquid sugar alcohols such as 70% sorbitol solution or glycol such as propylene glycol, hexylene glycol, di-, tri- or polyethylene glycol having a molecular weight from 76 to 600, optionally 0.5 to 2 moles of an alkaline reacting substance and other drug additives; 2. solid formulations of glibenclamide consisting of 1 part of glibenclamide, 4 to 30 parts of sugar alcohols, preferably 70% sorbitol solution, optionally dilute in alcohol, 30 to 150 parts of pharmacologically safe excipients, carrier mterials or other drug additives; and this invention also relates to a process for the production of a molecularly disperse solution or active substance alloy of glibenclamide or another sparingly soluble substance selected from the group consisting of sulfonyl ureas or substances and/or compounds having similar chemico-physical properties.