Vector containing DNA encoding mature human protein S

US5258288A · kind A · utility

Assignee

• Genzyme Corporation · US

Inventors

• Robert Michael Wydro · Foster City, US
• Edward H. Cohen · Belmont, US
• William Dackowski · Hopkinton, US
• Johan Stenflo · Malmö, SE
• Ake Lundwall · Lund, SE
• Bjorn Dahlback · Malmö, SE

Key dates

• Filing date: Jul 25, 1986
• Grant date: Nov 2, 1993
• Expiry date: Jul 25, 2006

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K14/745
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

Disclosed are a transformed mammalian cell that produces biologically active Protein S, and a vector for effecting the transformation of the cell. produces biologically active human Protein S, and the vector used to effect the transgenesis of the cell. The vector disclosed includes DNA encoding mature human Protein S, under the transcriptional control of a eukaryotic metallothionein gene, and also includes the transforming region of the bovine papilloma virus genome, and a fragment of SV40 DNA.