Bidirectional pox virus promoter element
US5258294A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Oct 9, 1990 |
| Grant date | Nov 2, 1993 |
| Priority date | — |
| Expiry date | Oct 9, 2010 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S424/826
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A gene sequence including a first promoter for the expression of a major early fowlpox virus (FPV) protein. In a preferred aspect, the gene sequence further includes a second promoter for the expression of a late fowlpox virus protein in opposite orientation to said first promoter. The promoter is useful in developing FPV based vectors for the delivery of vaccine antigens preferably to poultry, and as a tool to study the temporal regulation of poxvirus genes. The invention also offers methods useful in the construction of recombinant fowlpox viruses or related avian poxviruses, which methods are characterized by the introduction of foreign DNA into the fowlpox virus or into virus DNA sequences, which sequences are able to use native FPV promoter regions.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.