O-aryl, O-alkyl, O-alkenyl and O-alkynylrapamycin derivatives
US5258389A · kind A · utility
204Cited by
14References
12Claims
0Family size
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Key dates
| Filing date | Nov 9, 1992 |
| Grant date | Nov 2, 1993 |
| Priority date | — |
| Expiry date | Nov 9, 2012 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D498/18
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
O-Aryl, O-alkyl, O-alkenyl and O-alkynylrapamycin derivatives of the general structural Formula I: ##STR1## have been prepared from suitable precursors by alkylation and/or arylation at C-42 and/or C-31. These compounds are useful in a mammalian host for the treatment of autoimmune diseases and diseases of inflammation, infectious diseases, the prevention of rejection of foreign organ transplants and the treatment of solid tumors.
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