3,4-disubstituted phenols-immunomodulating agents
US5258407A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Dec 31, 1991 |
| Grant date | Nov 2, 1993 |
| Priority date | — |
| Expiry date | Dec 31, 2011 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C2603/74
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Certain 3,4-disubstituted phenols and pharmaceutically acceptable salts thereof are provided which mimic IL-1 activity by inducing IL-2 synthesis and subsequent IL-2 receptor expression. Specifically, the invention provides compounds of Formula I and acid addition salts thereof: ##STR1## wherein Y is ##STR2## NHSO.sub.2 or SO.sub.2 NH where R.sup.4 is H; Z is --O--, --NH--, --NR--, --S--, or other heteroatoms capable of hydrogen bonding with R.sup.4 to give a preferred conformation; PA0 R is alkyl; PA0 R.sup.1 is --OH; PA0 R.sup.2 is H, alkyl, cycloalkyl, aralkyl, substituted or unsubstituted aryl, or a substituted or unsubstituted nitrogen heterocyclic group having 4 to 5 nuclear carbon atoms; and PA0 R.sup.3 is a lipophilic moiety.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.