Imidazopyridines as serotonergic 5-HT.sub.3 antagonists
US5260303A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Mar 7, 1991 |
| Grant date | Nov 9, 1993 |
| Priority date | — |
| Expiry date | Mar 7, 2011 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P43/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The imidazopyridines compounds of the present invention are serotonergic 5-HT.sub.3 antagonists. As such they are useful for the treatment of humans and animals wherein antagonism of 5-HT.sub.3 receptors is beneficial. Therapy is indicated for, but not limited to, the treatment of anxiety, psychoses, depression (especially depression accompanied by anxiety), cognitive disorders, substance abuse dependence and withdrawal, gastrointestinal motility disturbancies (including esophageal reflux, dyspepsia, gastric stasis, irritable bowel syndrome), emesis caused by chemotherapeutic agents, and visceral pain. Additionally, the compounds of the present invention may find utility as enhancers of nasal absorption of bioactive compounds.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.