Anthracycline derivatives having cytostatic activity

US5260425A · kind A · utility

Assignee

• Behringwerke Aktiengesellschaft · DE

Inventors

• Peter Hermentin · Marburg, DE
• Ernst Raab · Lahntal, DE
• Cenek Kolar · Marburg, DE
• Manfred Gerken · Marburg, DE
• Dieter Hoffmann · Marburg, DE
• Hans Kraemer · Marburg, DE
• Ulrich Stache

Key dates

• Filing date: Jun 2, 1989
• Grant date: Nov 9, 1993
• Expiry date: Jun 2, 2009

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07H15/26
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention relates to new anthracycline derivatives having cytostatic activity and the general formula I, ##STR1## which can optionally also be in the form of an acid addition salt of physiologically acceptable inorganic or organic acids, where R.sup.1 is hydrogen or a hydroxyl group, R.sup.2 is hydrogen, a hydroxyl or a methoxy group, R.sup.3 is hydrogen or a hydroxyl group, R.sup.4 is hydrogen or a hydroxyl group, R.sup.5 hydrogen, a hydroxyl or a methoxycarbonyl group, R.sup.6 is CH.sub.2 CH.sub.3, COCH.sub.3, COCH.sub.2 OH, CHOHCH.sub.3 or CHOHCH.sub.2 OH and R.sup.7 is an organic substituent which has 2 to 6 carbon atoms and which contains at least one oxygen, nitrogen or sulfur atom or a C--C double bond or a C--C triple bond, it being possible for the double bond also to be a constituent of a heteroaromatic system and for the oxygen, nitrogen or sulfur atom to be a constituent of an open-chain or heterocyclic system, to a process for the preparation thereof and to the use thereof in a pharmaceutical.