Polyhydroxycyclopentane derivatives, their preparation and their therapeutic use
US5260447A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Feb 13, 1992 |
| Grant date | Nov 9, 1993 |
| Priority date | — |
| Expiry date | Feb 13, 2012 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C2601/06
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
5-Amino-1-(hydroxymethyl)cyclopentane-1,2,3,4-tetraol and 2-amino-4-(hydroxymethyl)-3a,5,6,6a-tetrahydro-4H-cyclopent[d]oxazole-4,5, 6-triol, which have the ability to inhibit the activity of sugar hydrolases, especially .beta.-glucosidase and sucrase and can thus be used for the treatment and prophylaxis of tumorous conditions, AIDS, diabetes and obesity, can be prepared by hydrolysis of trehazolin. 2-Amino-4-(hydroxymethyl)-3a,5,6,6a-tetrahydro-4H-cyclopent[d]oxazole-4,5, 6-triol can also be prepared by fermentation using newly isolated strains Micromonospora sp. SANK 62390, FERM BP-3521 and Amycolatopsis sp. SANK 60791, FERM BP-3513.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.