Method for preparing 7-oxabicycloheptyl substituted bromooxazole amide prostaglandin analog intermediates useful in the preparation of anti-thrombotic and anti-vasospastic compounds
US5260449A · kind A · utility
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3References
29Claims
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Key dates
| Filing date | Aug 12, 1992 |
| Grant date | Nov 9, 1993 |
| Priority date | — |
| Expiry date | Aug 12, 2012 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D493/08
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A method is provided for preparing bromooxazole intermediates of the structure ##STR1## wherein a vinyl compound of the structure ##STR2## wherein X.sup.1 and X.sup.2 are independently H and Br, is treated with a metal halide such as cupric bromide, and a base such as 1,8-diazabicyclo-[5.4.0]undec-7-ene (DBU). The resulting bromooxazole may be hydrolyzed and hydrogenolyzed to the final anti-thrombotic-anti-vasospastic compounds.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.